Oral surgery, oral medicine, oral pathology and oral radiology · 2012
Aberrant keratinization of reticular oral lichen planus is related to elastolysis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Liao Shih-Chung, Hsieh Po-Chen, Huang Jehn-Shyun, Hsu Chia-Wen, Yuan Kuo
Аннотация
OBJECTIVE: Aberrant keratinization is common in oral lichen planus (OLP) on buccal mucosa. Because elastin is crucial for maintaining the nonkeratinized phenotype of oral mucosa, we examined whether inflammatory elastases and the accompanying elastolysis were related to this feature.
STUDY DESIGN: Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization-associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions.
RESULTS: The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin.
CONCLUSIONS: Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.
STUDY DESIGN: Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization-associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions.
RESULTS: The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin.
CONCLUSIONS: Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.