Archives of pathology & laboratory medicine · 2018
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Hui Pei
Аннотация
CONTEXT.—: Gestational trophoblastic tumors include 3 distinct entities: gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Accurate diagnosis is important for clinical management of the patient.
OBJECTIVE.—: To review clinical features and pathologic diagnosis of gestational trophoblastic tumors.
DATA SOURCES.—: Literature and personal experience are the sources for this study.
CONCLUSIONS.—: Trophoblastic tumors are rare encounters in modern medicine, as a result of clinical practice of molar surveillance programs and early chemotherapeutic intervention for persistent gestational trophoblastic neoplasia. Diagnostic recognition of these tumors requires a high index of suspicion, awareness of their histologic characteristics, and appropriate application of immunohistochemical and molecular biomarkers. Recent attention has been given to a few precursor lesions of gestational trophoblastic tumors, including early/in situ choriocarcinoma and atypical placental site nodule.
OBJECTIVE.—: To review clinical features and pathologic diagnosis of gestational trophoblastic tumors.
DATA SOURCES.—: Literature and personal experience are the sources for this study.
CONCLUSIONS.—: Trophoblastic tumors are rare encounters in modern medicine, as a result of clinical practice of molar surveillance programs and early chemotherapeutic intervention for persistent gestational trophoblastic neoplasia. Diagnostic recognition of these tumors requires a high index of suspicion, awareness of their histologic characteristics, and appropriate application of immunohistochemical and molecular biomarkers. Recent attention has been given to a few precursor lesions of gestational trophoblastic tumors, including early/in situ choriocarcinoma and atypical placental site nodule.