The Clinical and Pathological Features of Maternal Gastric Adenocarcinoma Metastatic to Placenta.

We describe two mothers with metastatic gastric carcinoma involving the placenta. The first was a 35-year-old woman, who presented with a progressive decline in serum fibrinogen level at 34 + 2gestation week and underwent an emergency cesarean section. The second case was a 30-year-old woman who developed intolerable lumbosacral pain and cesarean section was performed at her 37 + 3gestation week. Gross pathological examinations of both placentas were normal, but microscopy showed poorly differentiated adenocarcinoma infiltration in the intervillous space, later proved to be gastric in origin. The neoplastic cells did not involve the villi, but were associated with massive perivillous fibrin. The two mothers died 180 and 19 days after the delivery. Both babies were free of metastatic carcinoma at 20- and 19-month follow-up.