European review for medical and pharmacological sciences · 2011
A preliminary study of the local treatment of preneoplastic and malignant skin lesions using methyl jasmonate.
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Palmieri B, Iannitti T, Capone S, Flescher E
Аннотация
BACKGROUND: Jasmonates are plant stress hormones. These small hydrophobic compounds exhibit anti-cancer activities, in vitro and in vivo, against cancer cells of various histological origins. Moreover, they show a selective activity against transformed cells and affect drug-resistant cells as well.
AIM: The aim of this study was to evaluate the activity of a powerful jasmonate derivative, that is methyl jasmonate.
MATERIAL AND METHODS: Methyl jasmonate was applied topically on cancerous and pre-cancerous skin lesions from eight patients.
RESULTS: Methyl jasmonate did not cause any meaningful local or systemic side effects. Three patients exhibited positive responses. Two patients had complete recovery and one had a recurrence of the lesion three months post treatment.
CONCLUSIONS: Methyl jasmonate is a potentially promising novel topical treatment for prcancerous and cancerous skin lesions. Methyl jasmonate should be evaluated in a larger series of patients.
AIM: The aim of this study was to evaluate the activity of a powerful jasmonate derivative, that is methyl jasmonate.
MATERIAL AND METHODS: Methyl jasmonate was applied topically on cancerous and pre-cancerous skin lesions from eight patients.
RESULTS: Methyl jasmonate did not cause any meaningful local or systemic side effects. Three patients exhibited positive responses. Two patients had complete recovery and one had a recurrence of the lesion three months post treatment.
CONCLUSIONS: Methyl jasmonate is a potentially promising novel topical treatment for prcancerous and cancerous skin lesions. Methyl jasmonate should be evaluated in a larger series of patients.
Предметные рубрики MeSH
AcetatesAgedAged, 80 and overAntineoplastic Agents, PhytogenicCarcinoma, Squamous CellCompassionate Use TrialsCyclopentanesFemaleHumansLentigoLeukoplakiaLichen Planus, OralMaleMiddle AgedNeoplasm Recurrence, LocalOxylipinsPilot ProjectsPrecancerous ConditionsSkin NeoplasmsTime FactorsTreatment Outcome