Journal of magnetic resonance imaging : JMRI · 2018
Reproducibility of native T1 mapping for renal tissue characterization at 3T.
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Dekkers Ilona A, Paiman Elisabeth H M, de Vries Aiko P J, Lamb Hildo J
Аннотация
BACKGROUND: Advanced renal disease is characterized by adverse changes in renal structure; however, noninvasive techniques to diagnose and monitor these changes are currently lacking.
PURPOSE: To evaluate the reproducibility of native T1 mapping for renal tissue characterization.
STUDY TYPE: Reproducibility study.
POPULATION: Fifteen healthy volunteers (mean age 31 years, range 19-63 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51-69 years).
FIELD STRENGTH/SEQUENCE: 3T, modified Look-Locker imaging (MOLLI) 5(3)3.
ASSESSMENT: Intra- and interexamination reproducibility of voxel-based T1 relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients.
STATISTICAL TESTS: Reproducibility was evaluated using Bland-Altman and intraclass correlation coefficients (ICCs).
RESULTS: Intra- and interexamination reproducibility of renal native T1 mapping showed good-strong ICCs (0.83-0.89) for renal cortex and medulla, and moderate-good ICCs (0.62-0.81) for cortex-medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra- and interexamination limits of agreement were respectively (-124 msec, + 82 msec) and (-134 msec, + 98 msec) for renal cortex and (-138 msec, + 107 msec) and (-118 msec, + 151 msec) for medulla. Overall T1 values for renal cortex (P = 0.277) and medulla (P = 0.973) were not significantly different between healthy volunteers and diabetic nephropathy patients, in contrast to the cortex-medulla ratio (P = 0.003).
DATA CONCLUSION: Renal native T1 mapping is a technique with good-strong intra- and examination reproducibility in both healthy volunteers and diabetic nephropathy patients.
LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:588-596.
PURPOSE: To evaluate the reproducibility of native T1 mapping for renal tissue characterization.
STUDY TYPE: Reproducibility study.
POPULATION: Fifteen healthy volunteers (mean age 31 years, range 19-63 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51-69 years).
FIELD STRENGTH/SEQUENCE: 3T, modified Look-Locker imaging (MOLLI) 5(3)3.
ASSESSMENT: Intra- and interexamination reproducibility of voxel-based T1 relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients.
STATISTICAL TESTS: Reproducibility was evaluated using Bland-Altman and intraclass correlation coefficients (ICCs).
RESULTS: Intra- and interexamination reproducibility of renal native T1 mapping showed good-strong ICCs (0.83-0.89) for renal cortex and medulla, and moderate-good ICCs (0.62-0.81) for cortex-medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra- and interexamination limits of agreement were respectively (-124 msec, + 82 msec) and (-134 msec, + 98 msec) for renal cortex and (-138 msec, + 107 msec) and (-118 msec, + 151 msec) for medulla. Overall T1 values for renal cortex (P = 0.277) and medulla (P = 0.973) were not significantly different between healthy volunteers and diabetic nephropathy patients, in contrast to the cortex-medulla ratio (P = 0.003).
DATA CONCLUSION: Renal native T1 mapping is a technique with good-strong intra- and examination reproducibility in both healthy volunteers and diabetic nephropathy patients.
LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:588-596.