Laser denudation as treatment for diffuse epithelial dysplasia of the glans penis.

We describe a new technique using the neodymium: YAG laser to denude the entire epithelium of the glans penis as a treatment for diffuse dysplasia of the glans. Epithelial regrowth originated from the healthy epithelium at the margins of the denudation. Six months after surgery the glans was covered by an entirely new epithelium, which was normal by histopathologic evaluation. Laser denudation was performed at a single outpatient session with minimal postoperative morbidity and produced excellent functional and cosmetic results. We believe this technique is an attractive alternative to partial penectomy for appropriate patients.