Coronary artery disease · 2018
Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Nakanishi Rine, Post Wendy S, Osawa Kazuhiro, Jayawardena Eranthi, Kim Michael, Sheidaee Nasim, Nezarat Negin, Rahmani Sina, Kim Nicholas, Hathiramani Nicolai, Susarla Shriraj, Palella Frank, Witt Mallory, Blaha Michael J, Brown Todd T, Kingsley Lawrence, Haberlen Sabina A, Dailing Christopher, Budoff Matthew J
Аннотация
BACKGROUND AND AIM: The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).
PATIENTS AND METHODS: HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.
CONCLUSION: We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
PATIENTS AND METHODS: HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.
CONCLUSION: We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.