Annals of hepatology · 2020
Is there an association between commonly employed biomarkers of liver fibrosis and liver stiffness in the general population?
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Foschi Francesco Giuseppe, Domenicali Marco, Giacomoni Pierluigi, Dall'Aglio Anna Chiara, Conti Fabio, Borghi Alberto, Bevilacqua Vittoria, Napoli Lucia, Mirici Federica, Cucchetti Alessandro, Ercolani Giorgio, Gardini Andrea Casadei, Bellentani Stefano, Gastaldelli Amalia, Giuffrè Mauro, Tiribelli Claudio, Bedogni Giorgio, Bagnacavallo Study Group
Аннотация
INTRODUCTION AND OBJECTIVES: Surrogate biomarkers of liver fibrosis developed in tertiary care are increasingly used in general populations. We evaluated the association between liver stiffness (LS) and five continuous (AST/ALT, APRI, Forns Index, FIB-4, GGT) and two discrete biomarkers (BARD, BAAT) in a general population.
PATIENTS AND METHODS: 636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens.
RESULTS: The mean change of LS between the 5th and 95th internal percentile of any continuous biomarker was ≤1kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1kPa but of doubtful clinical relevance.
CONCLUSION: We found a modest association between LS and seven biomarkers of liver fibrosis in a general population.
PATIENTS AND METHODS: 636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens.
RESULTS: The mean change of LS between the 5th and 95th internal percentile of any continuous biomarker was ≤1kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1kPa but of doubtful clinical relevance.
CONCLUSION: We found a modest association between LS and seven biomarkers of liver fibrosis in a general population.