Regional Patterns and Association Between Obesity and Hypertension in Africa: Evidence From the H3Africa CHAIR Study.
Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Akpa Onoja M, Made Felix, Ojo Akinlolu, Ovbiagele Bruce, Adu Dwomoa, Motala Ayesha A, Mayosi Bongani M, Adebamowo Sally N, Engel Mark E, Tayo Bamidele, Rotimi Charles, Salako Babatunde, Akinyemi Rufus, Gebregziabher Mulugeta, Sarfo Fred, Wahab Kolawole, Agongo Godfred, Alberts Marianne, Ali Stuart A, Asiki Gershim, Boua Romuald P, Gómez-Olivé F Xavier, Mashinya Felistas, Micklesfield Lisa, Mohamed Shukri F, Nonterah Engelbert A, Norris Shane A, Sorgho Hermann, Tollman Stephen, Parekh Rulan S, Chishala Chishala, Ekoru Kenneth, Waddy Salina P, Peprah Emmanuel, Mensah George A, Wiley Ken, Troyer Jennifer, Ramsay Michèle, Owolabi Mayowa O, as members of the CVD Working Group of the H3Africa Consortium
Аннотация
Hypertension and obesity are the most important modifiable risk factors for cardiovascular diseases, but their association is not well characterized in Africa. We investigated regional patterns and association of obesity with hypertension among 30 044 continental Africans. We harmonized data on hypertension (defined as previous diagnosis/use of antihypertensive drugs or blood pressure [BP]≥140/90 mmHg/BP≥130/80 mmHg) and obesity from 30 044 individuals in the Cardiovascular H3Africa Innovation Resource across 13 African countries. We analyzed data from population-based controls and the Entire Harmonized Dataset. Age-adjusted and crude proportions of hypertension were compared regionally, across sex, and between hypertension definitions. Logit generalized estimating equation was used to determine the independent association of obesity with hypertension (P value <5%). Participants were 56% women; with mean age 48.5±12.0 years. Crude proportions of hypertension (at BP≥140/90 mmHg) were 47.9% (95% CI, 47.4-48.5) for Entire Harmonized Dataset and 42.0% (41.1-42.7) for population-based controls and were significantly higher for the 130/80 mm Hg threshold at 59.3% (58.7-59.9) in population-based controls. The age-adjusted proportion of hypertension at BP≥140/90 mmHg was the highest among men (33.8% [32.1-35.6]), in western Africa (34.7% [33.3-36.2]), and in obese individuals (43.6%; 40.3-47.2). Obesity was independently associated with hypertension in population-based controls (adjusted odds ratio, 2.5 [2.3-2.7]) and odds of hypertension in obesity increased with increasing age from 2.0 (1.7-2.3) in younger age to 8.8 (7.4-10.3) in older age. Hypertension is common across multiple countries in Africa with 11.9% to 51.7% having BP≥140/90 mmHg and 39.5% to 69.4% with BP≥130/80 mmHg. Obese Africans were more than twice as likely to be hypertensive and the odds increased with increasing age.