GMS hygiene and infection control · 2025
Virulent genes related to the synthesis of community interaction factors among clinical samples of multidrug-resistant Acinetobacter baumannii in Iran.
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Azimi Leila, Hasani Hadi, Karimi Abdollah, Fahimzad Seyed Alireza, Rezaei Ali, Fallah Fatemeh, Fatehi Shima, Armin Shahnaz, Sadr Mohammadreza
Аннотация
INTRODUCTION: Acinetobacter (A.) baumannii poses a significant threat of resistance to multiple antibiotics. This study aimed to examine the prevalence of the abaI and bap genes in clinical isolates of multidrug-resistant A. baumannii collected from 10 cities in Iran.
METHOD: Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method, and multidrug resistance was confirmed using specific criteria. The presence of abaI and bap genes was identified through conventional PCR.
RESULTS: Of 50 samples total, 62% were from males, and 38% were from females, with most isolates originating from ICUs and obtained from the tracheobronchial tract. The abaI gene was present in 94% of samples, while the bap gene was present in 88%. Statistical analysis showed no significant differences in gene frequencies and antibiotic resistance patterns.
CONCLUSIONS: The presence of abaI or bap genes was not related to antibiotic resistance. However, the frequency of these virulent genes was relatively high among multi-drug resistant A. baumannii samples. The differences in antibiotic resistance patterns of this bacterium show the need for future research in this field.
METHOD: Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method, and multidrug resistance was confirmed using specific criteria. The presence of abaI and bap genes was identified through conventional PCR.
RESULTS: Of 50 samples total, 62% were from males, and 38% were from females, with most isolates originating from ICUs and obtained from the tracheobronchial tract. The abaI gene was present in 94% of samples, while the bap gene was present in 88%. Statistical analysis showed no significant differences in gene frequencies and antibiotic resistance patterns.
CONCLUSIONS: The presence of abaI or bap genes was not related to antibiotic resistance. However, the frequency of these virulent genes was relatively high among multi-drug resistant A. baumannii samples. The differences in antibiotic resistance patterns of this bacterium show the need for future research in this field.