Generation of iPSC line CSUASOi015-A from peripheral blood mononuclear cells of an autosomal dominant retinitis pigmentosa patient with a heterozygous deletion of exons 2-8 in PRPF31.

Retinitis pigmentosa (RP) is an inherited retinal degenerative disease causing progressive visual dysfunction. Here, we generated a human induced pluripotent stem cell (iPSC) line, CSUASOi015-A, from peripheral blood mononuclear cells of a 46-year-old male patient with autosomal dominant RP carrying a heterozygous deletion of exons 2-8 in PRPF31. The established iPSC line retained the donor-specific PRPF31 variant and exhibited normal undifferentiated hPSC state, trilineage differentiation potential, and karyotype. This cell line provides a useful in vitro model for investigating the pathogenic mechanisms of PRPF31-associated RP.