Influenza and other respiratory viruses · 2026
A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir.
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Hussain Saira, Chia Charmaine, Muraleetharan Ashwin, Deng Yi-Mo, Dong Xiaomin, Chanthalavanh Presa, Takashita Emi, Dapat Clyde, Miller Jessica E, Peck Heidi, Lee Raphael T C, Williamson Jan, Cooley Louise, Maurer-Stroh Sebastian, Barr Ian G
Аннотация
The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, with a PA gene mutation A37T that showed mild reductions in susceptibility in vitro to baloxavir (3.47- to 16.33-fold increased EC50) when compared to wild-type influenza A(H3N2) viruses. When the PA-A37T and PA-I38T substitutions were combined and tested in IRINA assay, eightfold higher inhibition was seen compared to PA-I38T alone. On-going monitoring of influenza viruses for reduced susceptibility to antivirals remains an important part of seasonal and zoonotic influenza surveillance.