Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014
Human metapneumovirus pneumonia in patients with hematological malignancies.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Godet Cendrine, Le Goff Jérôme, Beby-Defaux Agnès, Robin Marie, Raffoux Emmanuel, Arnulf Bertrand, Roblot France, Frat Jean Pierre, Maillard Natacha, Tazi Abdellatif, Bergeron Anne
Аннотация
BACKGROUND: Human metapneumovirus (HMPV) has recently emerged as a cause of respiratory infections in hematological patients. Clinical data are lacking to guide the management of HMPV pneumonias.
OBJECTIVES: To characterize the clinical and radiographic presentation and outcome of HMPV pneumonias diagnosed in hematological patients.
STUDY DESIGN: We screened the patients with a positive HMPV respiratory test in two French teaching hospitals between 2007 and 2011. Among them, the medical charts from the hematological patients who presented with HMPV pneumonia were reviewed.
RESULTS: Among the 54 patients with several underlying hematological conditions who were positive for HMPV, we found 13 cases of HMPV pneumonias. HMPV could be the cause of pneumonia as a single pathogen without associated upper respiratory infection. Centrilobular nodules were constant on lung computed tomography scans. No patients died despite the absence of administration of antiviral treatments.
CONCLUSIONS: Our data provide further insights in the diagnosis and management of HMPV pneumonias in this setting.
OBJECTIVES: To characterize the clinical and radiographic presentation and outcome of HMPV pneumonias diagnosed in hematological patients.
STUDY DESIGN: We screened the patients with a positive HMPV respiratory test in two French teaching hospitals between 2007 and 2011. Among them, the medical charts from the hematological patients who presented with HMPV pneumonia were reviewed.
RESULTS: Among the 54 patients with several underlying hematological conditions who were positive for HMPV, we found 13 cases of HMPV pneumonias. HMPV could be the cause of pneumonia as a single pathogen without associated upper respiratory infection. Centrilobular nodules were constant on lung computed tomography scans. No patients died despite the absence of administration of antiviral treatments.
CONCLUSIONS: Our data provide further insights in the diagnosis and management of HMPV pneumonias in this setting.