Journal of cardiac failure · 2024
Baroreflex Function in Cardiovascular Disease.
СтатьяОбзорПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Salah Husam M, Gupta Richa, Hicks Albert J, Mahmood Kiran, Haglund Nicholas A, Bindra Amarinder S, Antoine Steve M, Garcia Rachel, Yehya Amin, Yaranov Dmitry M, Patel Pujan P, Feliberti Jason P, Rollins Allman T, Rao Vishal N, Letarte Laurie, Raje Vikram, Alam Amit H, McCANN Patrick, Raval Nirav Y, Howard Brian, Fudim Marat
Аннотация
The baroreflex system is involved in modulating several physiological functions of the cardiovascular system and can modulate cardiac output, blood pressure, and cardiac electrophysiology directly and indirectly. In addition, it is involved in regulating neurohormonal pathways involved in the cardiovascular function, such as the renin-angiotensin-aldosterone system and vasopressin release. Baroreflex dysfunction is characterized by sympathetic overactivation and parasympathetic withdrawal and is associated with several cardiovascular diseases, such as hypertension, heart failure, and coronary artery disease. Targeting the baroreflex system via invasive (eg, baroreflex activation therapy and endovascular baroreceptor amplification) and noninvasive approaches (eg, slow breathing exercises and exercise training) has emerged as a novel pathway to manage cardiovascular diseases. Studies examining the long-term safety and efficacy of such interventions in various cardiovascular diseases are needed.