Factors Influencing the Mental Health Status of Hepatocellular Carcinoma Patients Undergoing Hepatectomy.

OBJECTIVE

To investigate the psychological status of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy, analyze risk factors for anxiety and depression, and provide a theoretical basis for individualized mental intervention strategies.

METHODS

A total of 412 HCC patients who underwent hepatectomy at Fuyang People's Hospital from January 2022 to January 2026 were enrolled. The Hospital Anxiety and Depression Scale (HADS) and FRAIL scale were used to assess psychological status and frailty, respectively. Univariate ANOVA and linear regression were performed to analyze relationships between anxiety, depression, and perioperative factors.

RESULTS

Of 456 distributed questionnaires, 412 were valid (response rate: 90.35%). Mean HADS-A (anxiety) score was 8.34 ± 2.79: 130 asymptomatic, 192 doubtful, and 90 definite cases. Mean HADS-D (depression) score was 8.68 ± 2.75: 187 asymptomatic, 96 doubtful, and 129 definite cases. Univariate analysis showed associations between anxiety/depression and family income, open surgery, FRAIL score, and complications. Multivariate analysis identified open surgery, FRAIL score, and complications as independent risk factors (p < 0.05).

CONCLUSION

Patients with HCC undergoing hepatectomy exhibited significant anxiety and depression symptoms. FRAIL score, open surgery, and complication severity were risk factors, warranting attention to postoperative negative emotions and timely intervention.