Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013
Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Evans Claire F, Davtyan Hayk, Petrushina Irina, Hovakimyan Armine, Davtyan Arpine, Hannaman Drew, Cribbs David H, Agadjanyan Michael G, Ghochikyan Anahit
Аннотация
BACKGROUND: Clinical trials with passive and active Alzheimer's disease (AD) vaccines suggest that early interventions are needed for improvement of cognitive and/or functional performance in patients, providing impetus for the development of safe and immunologically potent active vaccines targeting amyloid β (Aβ). The AN-1792 trial has indicated that Aβ-specific T cells may be unsafe for humans; therefore, other vaccines based on small Aβ epitopes are undergoing preclinical and clinical testing.
METHODS: Humoral and cellular immune responses elicited in response to a novel DNA epitope-based vaccine (AV-1955) delivered to rhesus macaques using the TriGrid electroporation device were evaluated. Functional activities of anti-Aβ antibodies generated in response to vaccination were assessed in vitro.
RESULTS: AV-1955 generates long-term, potent anti-Aβ antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Aβ.
CONCLUSIONS: This translational study demonstrates that a DNA-based epitope vaccine for AD could be appropriate for human clinical testing.
METHODS: Humoral and cellular immune responses elicited in response to a novel DNA epitope-based vaccine (AV-1955) delivered to rhesus macaques using the TriGrid electroporation device were evaluated. Functional activities of anti-Aβ antibodies generated in response to vaccination were assessed in vitro.
RESULTS: AV-1955 generates long-term, potent anti-Aβ antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Aβ.
CONCLUSIONS: This translational study demonstrates that a DNA-based epitope vaccine for AD could be appropriate for human clinical testing.
Предметные рубрики MeSH
Alzheimer DiseaseAlzheimer VaccinesAmyloid beta-PeptidesAnimalsAntibodiesCell Line, TumorDose-Response Relationship, ImmunologicEpitopes, T-LymphocyteHumansImmunoglobulin GLongitudinal StudiesLymphocyte ActivationMacaca mulattaMalePlaque, AmyloidRandom AllocationT-Lymphocytes, Helper-InducerTime FactorsTranslational Research, BiomedicalVaccines, DNA