Effect of E 600 and Toxobidin on the behavious of cholinesterases in mouse skeletal muscles in the course of experimental trichinellosis.

Experiments were carried out on mice between the 14th and the 19th day following the infection with Trichinella larvae. E 600 was given in the lowest lethal dose (0-8 mg/kg) and Toxobidin in a curative dose of 15 mg/kg. The activities of AChE and PChE were examined with the use of the substrates of acetylthiocholine and butrylthiocholine iodides (Koelle-Friedenwald's method in Gomori's modification). Toxobidin was found to influence significantly restitution of AChE activity. The mice which had received E 600 under the protection of Toxobidin exhibited but a slight degree of inhibition of AChE activity. However, Toxobidin was not observed to exert a substantial effect on restitution of PChE activity. It is also worthy of note that Toxobidin has a great protective power. No animal died in the experimental group treated with E 600 under the protection of Toxobidin. On the other hand, in the group which had received E 600 only, all animals died within 10 to 15 minutes.