The journal of contemporary dental practice · 2019
Impact of Weight Reduction on Adiponectin and TNF-α Levels in the Gingival Crevicular Fluids of Obese Patients with and without Periodontal Disease.
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Vivekannada Lalith, Faizuddin Mohamed
Аннотация
AIM: The aim of the current study was to assess the impact of weight loss on the gingival crevicular fluids (GCF) levels of adiponectin and TNF-α in obese patients with periodontal disease.
MATERIALS AND METHODS: Sixty obese subjects were recruited into the study and were divided into three groups of 20 each. Group 1-periodontally healthy obese patients, group 2-obese patients with gingivitis, group 3-obese patients with periodontitis. The GCF levels of adiponectin and tumor necrosis factor α (TNF-α) were evaluated using ELISA, and the same was correlated with the probing pocket depth (PPD) and clinical attachment loss (CAL) at baseline and after attainment of ≥10% weight reduction.
RESULTS: Reductions in body weight resulted in elevated adiponectin and reduced TNF-α levels in the GCF. Adiponectin levels showed significant positive correlations and TNF-α negative correlation with improved periodontal parameters.
CONCLUSION: Weight reduction has an impact on obesity-related inflammatory changes on periodontal disease.
CLINICAL SIGNIFICANCE: Obesity can be a potential risk factor for periodontitis, weight reduction measures can considerably reduce the inflammatory burden on the periodontium.
MATERIALS AND METHODS: Sixty obese subjects were recruited into the study and were divided into three groups of 20 each. Group 1-periodontally healthy obese patients, group 2-obese patients with gingivitis, group 3-obese patients with periodontitis. The GCF levels of adiponectin and tumor necrosis factor α (TNF-α) were evaluated using ELISA, and the same was correlated with the probing pocket depth (PPD) and clinical attachment loss (CAL) at baseline and after attainment of ≥10% weight reduction.
RESULTS: Reductions in body weight resulted in elevated adiponectin and reduced TNF-α levels in the GCF. Adiponectin levels showed significant positive correlations and TNF-α negative correlation with improved periodontal parameters.
CONCLUSION: Weight reduction has an impact on obesity-related inflammatory changes on periodontal disease.
CLINICAL SIGNIFICANCE: Obesity can be a potential risk factor for periodontitis, weight reduction measures can considerably reduce the inflammatory burden on the periodontium.