Impact of Weight Reduction on Adiponectin and TNF-α Levels in the Gingival Crevicular Fluids of Obese Patients with and without Periodontal Disease.

AIM: The aim of the current study was to assess the impact of weight loss on the gingival crevicular fluids (GCF) levels of adiponectin and TNF-α in obese patients with periodontal disease.

MATERIALS AND

METHODS

Sixty obese subjects were recruited into the study and were divided into three groups of 20 each. Group 1-periodontally healthy obese patients, group 2-obese patients with gingivitis, group 3-obese patients with periodontitis. The GCF levels of adiponectin and tumor necrosis factor α (TNF-α) were evaluated using ELISA, and the same was correlated with the probing pocket depth (PPD) and clinical attachment loss (CAL) at baseline and after attainment of ≥10% weight reduction.

RESULTS

Reductions in body weight resulted in elevated adiponectin and reduced TNF-α levels in the GCF. Adiponectin levels showed significant positive correlations and TNF-α negative correlation with improved periodontal parameters.

CONCLUSION

Weight reduction has an impact on obesity-related inflammatory changes on periodontal disease.

CLINICAL SIGNIFICANCE: Obesity can be a potential risk factor for periodontitis, weight reduction measures can considerably reduce the inflammatory burden on the periodontium.