Academic radiology · 2017
Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.
СтатьяКомментарийНазвание и аннотация: Перевод пока не подготовлен
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Fabes Jeremy, Matthews Lucy, Filippini Nicola, Talbot Kevin, Jenkinson Mark, Turner Martin R
Аннотация
RATIONALE AND OBJECTIVES: T2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes.
MATERIALS AND METHODS: Thirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.
RESULTS: Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.
CONCLUSIONS: FLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.
MATERIALS AND METHODS: Thirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.
RESULTS: Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.
CONCLUSIONS: FLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.