Guillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Filosto Massimiliano, Cotti Piccinelli Stefano, Gazzina Stefano, Foresti Camillo, Frigeni Barbara, Servalli Maria Cristina, Sessa Maria, Cosentino Giuseppe, Marchioni Enrico, Ravaglia Sabrina, Briani Chiara, Castellani Francesca, Zara Gabriella, Bianchi Francesca, Del Carro Ubaldo, Fazio Raffaella, Filippi Massimo, Magni Eugenio, Natalini Giuseppe, Palmerini Francesco, Perotti Anna Maria, Bellomo Andrea, Osio Maurizio, Scopelliti Giuseppe, Carpo Marinella, Rasera Andrea, Squintani Giovanna, Doneddu Pietro Emiliano, Bertasi Valeria, Cotelli Maria Sofia, Bertolasi Laura, Fabrizi Gian Maria, Ferrari Sergio, Ranieri Federico, Caprioli Francesca, Grappa Elena, Broglio Laura, De Maria Giovanni, Leggio Ugo, Poli Loris, Rasulo Frank, Latronico Nicola, Nobile-Orazio Eduardo, Padovani Alessandro, Uncini Antonino
Аннотация
METHODS: GBS cases diagnosed in 12 referral hospitals from Lombardy and Veneto in March and April 2020 were retrospectively collected. As a control population, GBS diagnosed in March and April 2019 in the same hospitals were considered.
RESULTS: Incidence of GBS in March and April 2020 was 0.202/100 000/month (estimated rate 2.43/100 000/year) vs 0.077/100 000/month (estimated rate 0.93/100 000/year) in the same months of 2019 with a 2.6-fold increase. Estimated incidence of GBS in COVID-19-positive patients was 47.9/100 000 and in the COVID-19-positive hospitalised patients was 236/100 000. COVID-19-positive patients with GBS, when compared with COVID-19-negative subjects, showed lower MRC sum score (26.3±18.3 vs 41.4±14.8, p=0.006), higher frequency of demyelinating subtype (76.6% vs 35.3%, p=0.011), more frequent low blood pressure (50% vs 11.8%, p=0.017) and higher rate of admission to intensive care unit (66.6% vs 17.6%, p=0.002).
CONCLUSIONS: This study shows an increased incidence of GBS during the COVID-19 outbreak in northern Italy, supporting a pathogenic link. COVID-19-associated GBS is predominantly demyelinating and seems to be more severe than non-COVID-19 GBS, although it is likely that in some patients the systemic impairment due to COVID-19 might have contributed to the severity of the whole clinical picture.