Journal of affective disorders · 2025
Factors associated with lifetime rapid cycling in bipolar disorder: Findings from the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study).
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Grover Sandeep, Avasthi Ajit, Chakravarty Rahul, Dan Amitava, Chakraborty Kaustav, Neogi Rajarshi, Desouza Avinash, Nayak Omkar, Praharaj Samir Kumar, Menon Vikas, Deep Raman, Bathla Manish, Subramanyam Alka A, Nebhinani Naresh, Ghosh Prosenjit, Lakdawala Bhavesh, Bhattacharya Ranjan
Аннотация
BACKGROUND: There is a lack of information about factors associated with Bipolar disorder (BD), Rapid Cycling (RC) course in the Indian context.
AIM: This study aimed to evaluate the prevalence and factors associated with BD-RC course using data from the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study).
METHODOLOGY: This was a secondary analysis of data obtained from the BiD-CoIN study to evaluate the factors associated with RC in bipolar disorder.
RESULTS: Out of the 773 patients, about 6 % of BD patients have RC in their lifetime. Factors associated with RC included: being unemployed/homemakers (p < 0.001), being non-Hindus (p = 0.001), longer duration of episodes (p < 0.001), higher number of total and depressive episodes (in a lifetime, per year of illness, first five years, and per year of illness in first five years) (p < 0.001), higher number of manic, hypomanic, and mixed episodes (in the lifetime and per year of illness), shorter duration of current remission (p = 0.01), higher severity of depressive episodes in a lifetime, higher depressive affective morbidity index (p < 0.001), lower severity of manic episodes (p = 0.003), higher level of overall disability (p = 0.01) and in the interpersonal relationship domain, more frequent first-lifetime episode of depressive polarity, more frequent breakthrough episodes (p = 0.001), seasonality of episodes (p < 0.001), suicidal attempts (p = 0.003), relapses due to poor medication adherence (p = 0.003), indeterminate predominant polarity, psychotic symptoms during episodes in a lifetime, higher likelihood of receiving lithium.
CONCLUSIONS: The prevalence of BD-RC course is lower compared to Western countries, but there are many similarities in the factors associated with RC in bipolar disorder between India and Western countries.
AIM: This study aimed to evaluate the prevalence and factors associated with BD-RC course using data from the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study).
METHODOLOGY: This was a secondary analysis of data obtained from the BiD-CoIN study to evaluate the factors associated with RC in bipolar disorder.
RESULTS: Out of the 773 patients, about 6 % of BD patients have RC in their lifetime. Factors associated with RC included: being unemployed/homemakers (p < 0.001), being non-Hindus (p = 0.001), longer duration of episodes (p < 0.001), higher number of total and depressive episodes (in a lifetime, per year of illness, first five years, and per year of illness in first five years) (p < 0.001), higher number of manic, hypomanic, and mixed episodes (in the lifetime and per year of illness), shorter duration of current remission (p = 0.01), higher severity of depressive episodes in a lifetime, higher depressive affective morbidity index (p < 0.001), lower severity of manic episodes (p = 0.003), higher level of overall disability (p = 0.01) and in the interpersonal relationship domain, more frequent first-lifetime episode of depressive polarity, more frequent breakthrough episodes (p = 0.001), seasonality of episodes (p < 0.001), suicidal attempts (p = 0.003), relapses due to poor medication adherence (p = 0.003), indeterminate predominant polarity, psychotic symptoms during episodes in a lifetime, higher likelihood of receiving lithium.
CONCLUSIONS: The prevalence of BD-RC course is lower compared to Western countries, but there are many similarities in the factors associated with RC in bipolar disorder between India and Western countries.