[Eruptive nevus in the course of Lyell syndrome].

INTRODUCTION

Eruptive nevus have been described after severe bullous cutaneous adverse drug reactions. We report herein a berloque-like nevus extension after toxic epidermal necrolysis.

CASE REPORT: A 23 year-old woman was hospitalized for toxic epidermal necrolysis. A blister was in contact with a nevus. Four months after healing, extension of the nevus was seen on the blister area.

DISCUSSION: During toxic epidermal necrolysis and healing: 1) cytokines and growth factors are produced favouring nevocytes proliferation; 2) macromolecules are exposed on the wound bed; 3) adhesion molecules are expressed on nevocytes, restricting cell migration on exposed macromolecules. Interaction between matrix macromolecules and adhesion molecules could explain the limitation of nevus extension.