Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2013
Cholangiocarcinoma of intrahepatic bile ducts with disseminated metastases in an African lion (Panthera leo).
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Lepri Elvio, Sforna Monica, Brachelente Chiara, Vitellozzi Giovanni
Аннотация
A cholangiocarcinoma is reported in an 18-yr-old, female African lion (Panthera leo). The primary tumor consisted of multifocal to coalescing, hepatic, white-yellow masses distributed throughout the liver lobes. Metastases were present in regional lymph nodes, peritoneal surface, and lungs. Histologically, the tumor was characterized by a tubular pattern with alcian- and periodic acid-Schiff-positive secretory material in cystic spaces. The neoplastic cells were positive to broad-spectrum cytokeratins. Histochemical and immunohistochemical stains were consistent with bile duct carcinoma. Biliary tumors arising from the gallbladder have been reported in lions. However, to the authors' knowledge, this is the first case of intrahepatic bile duct carcinoma reported in an African lion.