68Ga-PSMA PET/CT in a case of recurrent Glioblastoma.

Glioblastoma multiforme (GBM) is a high-grade brain tumor with a high recurrence rate. We present the case of a 57-year-old man with left frontal lobe GBM who was operated on and received radiation therapy in June 2023 and was referred for 68Ga-PSMA 11 PET/CT with a clinical suspicion of recurrence. The scan showed intense tracer uptake in the left frontal lobe lesion with severe edema, which was consistent with recurrence. Our case underscores the role of 68Ga PSMA 11 PET/CT imaging of suspected glioblastoma recurrence which is the initial step in GBM theranostics with PSMA.