Occupational and environmental medicine · 1995
Platinum salt sensitivity in refinery workers: incidence and effects of smoking and exposure.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Calverley A E, Rees D, Dowdeswell R J, Linnett P J, Kielkowski D
Аннотация
OBJECTIVE: To measure the incidence of platinum salt sensitivity (PSS) in refinery workers and examine the influence of cigarette smoking and exposure to platinum salts on sensitisation.
DESIGN: A prospective cohort study with examination of workers at quarterly intervals for 18 months, and again at 24 months.
SETTING: A South African primary platinum refinery.
SUBJECTS: 78 new recruits, selected by the refinery's usual procedure, without apparent atopy and in good respiratory health.
RESULTS: After 24 months 32 (41%) subjects had been diagnosed PSS and were subsequently medically separated. Twenty two (28%) cases were confirmed by positive skin prick test to platinum salts, 10 (13%) cases were symptomatic but skin prick negative. Incidence of cases per 100 person-months was 1.9 skin prick positive and 0.8 negative. Risk of sensitisation was about eight times greater for smokers than non-smokers, and six times greater for high exposure than low exposure.
CONCLUSION: Smoking and intensity of exposure were definitely associated with development of PSS. Positive responses to platinum salt skin prick test had a 100% positive predictive value for symptoms and signs of PSS if exposure continued.
DESIGN: A prospective cohort study with examination of workers at quarterly intervals for 18 months, and again at 24 months.
SETTING: A South African primary platinum refinery.
SUBJECTS: 78 new recruits, selected by the refinery's usual procedure, without apparent atopy and in good respiratory health.
RESULTS: After 24 months 32 (41%) subjects had been diagnosed PSS and were subsequently medically separated. Twenty two (28%) cases were confirmed by positive skin prick test to platinum salts, 10 (13%) cases were symptomatic but skin prick negative. Incidence of cases per 100 person-months was 1.9 skin prick positive and 0.8 negative. Risk of sensitisation was about eight times greater for smokers than non-smokers, and six times greater for high exposure than low exposure.
CONCLUSION: Smoking and intensity of exposure were definitely associated with development of PSS. Positive responses to platinum salt skin prick test had a 100% positive predictive value for symptoms and signs of PSS if exposure continued.