Pharmacogenetics in advanced Parkinson's disease.

Parkinson's disease (PD) is a progressive neurodegenerative disorder with a wide variety of symptoms and evolution. In addition, the response to antiparkinsonian medication is not predictable, especially for those patients with advanced PD. Pharmacogenetics and pharmacogenomics may help to decide the best available treatment based on the genetic background of the patients. This approach has been already used in Oncology leading to personalized pharmacology. In this article, we review and comment the updated information regarding pharmacogenetics and pharmacogenomics applied to PD.