Anais brasileiros de dermatologia · 2026
Squamous cell carcinoma in chronic lesions of recalcitrant chromoblastomycosis. Study of ten patients treated at the Dermatological Center of Yucatán, Mexico.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Calderón Quiroz Eduardo Rafael, Torres Guerrero Edoardo, Proy Trujillo Héctor, Vega Memije María Elisa, Atoche Diéguez Carlos
Аннотация
BACKGROUND: Chromoblastomycosis is a chronic granulomatous fungal infection of the skin and subcutaneous tissue caused by dematiaceous fungi of the family Herpotrichiellaceae. It is considered an occupational disease, predominantly affecting male agricultural workers, with a worldwide distribution, especially in tropical and subtropical regions. Fonsecaea pedrosoi accounts for approximately 90% of reported cases.
OBJECTIVE: To describe the etiological agents, clinical features, and major complications associated with chromoblastomycosis.
METHODS: A retrospective, descriptive, and observational study presenting a case series was conducted, focusing on the pathogenesis, clinical presentation, disease course, and reported complications of chromoblastomycosis.
RESULTS: A total of 131 cases of chromoblastomycosis were documented; 10 patients (7.65%) developed squamous cell carcinoma. The mean age was 65.8-years, and the mean disease duration prior to malignant transformation was 17.4-years. The most frequently affected site was the upper limb (70%), followed by the lower limb (20%) and the trunk (10%).
STUDY LIMITATIONS: The descriptive nature of this review limits causal inference and precise estimation of malignant transformation rates.
CONCLUSION: Chromoblastomycosis is a chronic, polymorphic cutaneous infection often diagnosed late, leading to long-standing disease and disabling sequelae. Malignant transformation to squamous cell carcinoma represents one of its most severe complications and may occur even in residual scars. Early diagnosis and prolonged follow-up are essential to reduce morbidity and prevent malignant progression.
OBJECTIVE: To describe the etiological agents, clinical features, and major complications associated with chromoblastomycosis.
METHODS: A retrospective, descriptive, and observational study presenting a case series was conducted, focusing on the pathogenesis, clinical presentation, disease course, and reported complications of chromoblastomycosis.
RESULTS: A total of 131 cases of chromoblastomycosis were documented; 10 patients (7.65%) developed squamous cell carcinoma. The mean age was 65.8-years, and the mean disease duration prior to malignant transformation was 17.4-years. The most frequently affected site was the upper limb (70%), followed by the lower limb (20%) and the trunk (10%).
STUDY LIMITATIONS: The descriptive nature of this review limits causal inference and precise estimation of malignant transformation rates.
CONCLUSION: Chromoblastomycosis is a chronic, polymorphic cutaneous infection often diagnosed late, leading to long-standing disease and disabling sequelae. Malignant transformation to squamous cell carcinoma represents one of its most severe complications and may occur even in residual scars. Early diagnosis and prolonged follow-up are essential to reduce morbidity and prevent malignant progression.