Journal of cardiovascular medicine (Hagerstown, Md.) · 2026
Wnt/β-catenin pathway in patients with acute myocardial infarction: a prospective cohort study (BETA-MI STUDY).
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Licordari Roberto, Irrera Natasha, Lofrumento Francesca, Perfetti Silvia, Procopio Maria Cristina, De Sarro Rosalba, Manganaro Roberta, Zito Concetta, Vizzari Giampiero, Carciotto Gabriele, Saporito Francesco, Dattilo Giuseppe, Larrubia-Valle Jose I, Alegre Oscar Barquero, Ruiz Fernando Puyol, Garcia Ruiz Maria Victoria, Pavon Francisco Javier, De Gregorio Cesare, De Luca Giuseppe, Carerj Scipione, Di Bella Gianluca, Micari Antonio, Costa Francesco
Аннотация
BACKGROUND: Myocardial infarction (MI) triggers fibrotic remodeling, impairing cardiac function and increasing the risk of heart failure. Although the Wnt/β-catenin signaling pathway modulates infarct healing and fibrosis in animal models, its role in human post-MI remodeling remains unexplored. This study investigates Wnt/β-catenin activation in acute MI and its association with clinical and laboratory markers of remodeling.
METHODS: Fifty patients were prospectively enrolled: 40 with ST-elevation MI (STEMI) and 10 matched controls with chronic coronary syndrome (CCS). Blood samples were collected at five time points: pre-percutaneous coronary intervention (PCI), post-PCI, day 3, discharge, and 45-day follow-up. Protein and transcript levels of β-catenin and DKK1 (encoded by CTNNB1 and DKK1) were measured. Echocardiographic, laboratory, and clinical outcomes were also assessed.
RESULTS: The mean patient age was 62 ± 8 years; 82% were men. STEMI patients had significantly higher β-catenin and DKK1 levels than CCS controls at all time points. In STEMI, β-catenin remained stable, while DKK1 showed a slight increase. Pre-PCI β-catenin protein levels independently predicted improved left-ventricular ejection fraction (LVEF) at follow-up.
CONCLUSION: β-catenin is elevated in STEMI patients and correlates with better post-MI LVEF, suggesting a potential role in myocardial repair. These findings support further investigation of the Wnt/β-catenin pathway as a prognostic biomarker or therapeutic target in postinfarction cardiac recovery.
METHODS: Fifty patients were prospectively enrolled: 40 with ST-elevation MI (STEMI) and 10 matched controls with chronic coronary syndrome (CCS). Blood samples were collected at five time points: pre-percutaneous coronary intervention (PCI), post-PCI, day 3, discharge, and 45-day follow-up. Protein and transcript levels of β-catenin and DKK1 (encoded by CTNNB1 and DKK1) were measured. Echocardiographic, laboratory, and clinical outcomes were also assessed.
RESULTS: The mean patient age was 62 ± 8 years; 82% were men. STEMI patients had significantly higher β-catenin and DKK1 levels than CCS controls at all time points. In STEMI, β-catenin remained stable, while DKK1 showed a slight increase. Pre-PCI β-catenin protein levels independently predicted improved left-ventricular ejection fraction (LVEF) at follow-up.
CONCLUSION: β-catenin is elevated in STEMI patients and correlates with better post-MI LVEF, suggesting a potential role in myocardial repair. These findings support further investigation of the Wnt/β-catenin pathway as a prognostic biomarker or therapeutic target in postinfarction cardiac recovery.
Предметные рубрики MeSH
HumansMaleMiddle AgedFemaleProspective Studiesbeta CateninWnt Signaling PathwayST Elevation Myocardial InfarctionAgedVentricular RemodelingPercutaneous Coronary InterventionVentricular Function, LeftIntercellular Signaling Peptides and ProteinsBiomarkersTime FactorsStroke VolumeCase-Control StudiesUp-RegulationTreatment Outcome