Endoscopic transorbital amygdalohippocampectomy for the resection of an epileptogenic lesion.

Anterior temporal lobectomy and selective amygdalohippocampectomy are standard treatments for refractory temporal lobe epilepsy. Yet, they carry risks of lateral temporal damage to both neocortical and white matter structures, including the optic radiations. This video details a case of endoscopic transorbital amygdalohippocampectomy performed to resect an epileptogenic lesion. This approach offers minimally invasive access to the medial temporal lobe along its longitudinal axis, while preserving the lateral temporal area. Postoperative MRI showed resection of most of the amygdala, including its superior portion, and the hippocampus up to the tectal plate. This minimally invasive technique provides a promising alternative to traditional open surgery. The video can be found here: https://stream.cadmore.media/r10.3171/2025.1.FOCVID24198.