Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
Prefrontal transcranial magnetic stimulation changes cortical excitability across local and distributed brain regions.
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Zhen Zhen, Guo Rui, Tan Bolin, Wang Ying, Shi Shuyan, Ye Yang, Che Xianwei
Аннотация
OBJECTIVE: This study sort to identify the continuous effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC-rTMS) on local and distributed brain activities.
METHODS: In a double-blinded and sham-controlled design, 24 participants received either a real or sham DLPFC-rTMS session, with concurrent TMS-EEG being recorded at baseline, 5 and 60 min after stimulation.
RESULTS: DLPFC stimulation induced immediate cortical excitability in the frontal regions, while a continuous effect was identified in the parietal cortex for up to 60 min. Moreover, this pattern of cortical excitability effects was reliably identified across TMS-induced field potentials and oscillations.
CONCLUSIONS: Single-session DLPFC stimulation induced both immediate and continuous cortical excitability effects for at least 60 min. The continuous cortical excitability change. was most prominent over the parietal cortices.
SIGNIFICANCE: These novel findings may inform the design of TMS treatment paradigms to optimise cortical excitability and potentially clinical efficacy.
METHODS: In a double-blinded and sham-controlled design, 24 participants received either a real or sham DLPFC-rTMS session, with concurrent TMS-EEG being recorded at baseline, 5 and 60 min after stimulation.
RESULTS: DLPFC stimulation induced immediate cortical excitability in the frontal regions, while a continuous effect was identified in the parietal cortex for up to 60 min. Moreover, this pattern of cortical excitability effects was reliably identified across TMS-induced field potentials and oscillations.
CONCLUSIONS: Single-session DLPFC stimulation induced both immediate and continuous cortical excitability effects for at least 60 min. The continuous cortical excitability change. was most prominent over the parietal cortices.
SIGNIFICANCE: These novel findings may inform the design of TMS treatment paradigms to optimise cortical excitability and potentially clinical efficacy.