Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.
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Goldenkoff Elana R, Deluisi Joseph A, Brissenden James A, Lee Taraz G, Polk Thad A, Taylor Stephan F, Hampstead Benjamin M, Vesia Michael
Аннотация
INTRODUCTION: Cortical paired associative stimulation (cPAS), repeated at spaced intervals and applied to the primary motor cortex (M1) and posterior parietal cortex (PPC), has a dose-dependent effect on corticomotor excitability in young adults. The present study investigated whether aging affects this additive (nonhomeostatic) metaplasticity by performing the same manipulation in a sample of older adults.
METHODS: In the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions. In the single-dose control cPAS condition, one session of the Hebbian-plasticity-induction cPAS protocol was followed by two sessions of a control non-Hebbian cPAS protocol. We measured motor-evoked potentials (MEPs) before and after each cPAS session.
RESULTS: Compared to a single dose of cPAS, the multi-dose cPAS protocol prevented the reduction in MEP amplitude, resulting in relatively greater corticomotor excitability following the Hebbian procedures. We did not find evidence for an increase in MEP amplitude after the repeated, spaced Hebbian-plasticity-induction cPAS protocol from baseline levels, suggesting reduced neuroplasticity in older adults compared to young adults.
CONCLUSION: Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.
SIGNIFICANCE: These findings provide insight into age-related differences in neuroplastic capacity in healthy humans.
METHODS: In the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions. In the single-dose control cPAS condition, one session of the Hebbian-plasticity-induction cPAS protocol was followed by two sessions of a control non-Hebbian cPAS protocol. We measured motor-evoked potentials (MEPs) before and after each cPAS session.
RESULTS: Compared to a single dose of cPAS, the multi-dose cPAS protocol prevented the reduction in MEP amplitude, resulting in relatively greater corticomotor excitability following the Hebbian procedures. We did not find evidence for an increase in MEP amplitude after the repeated, spaced Hebbian-plasticity-induction cPAS protocol from baseline levels, suggesting reduced neuroplasticity in older adults compared to young adults.
CONCLUSION: Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.
SIGNIFICANCE: These findings provide insight into age-related differences in neuroplastic capacity in healthy humans.