Tropical gastroenterology : official journal of the Digestive Diseases Foundation · 2010
Comparison of 7 staging systems in north Indian cohort of hepatocellular carcinoma.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Sarma Sanjay, Sharma Balkrishan, Chawla Yogesh Kumar, Kapil Shweta, Singla Bhupesh, Kalra Naveen, Behera Arunashu, Duseja Ajay, Dhiman Radha Krishan
Аннотация
BACKGROUND & AIM: Many liver staging systems have been proposed for patients with hepatocellular carcinoma (HCC); however it is still controversial which staging system is best. The aim of this study was to compare the ability of 7 different staging systems in predicting survival in an Indian cohort of patients with HCC.
METHODS: In this prospective study, 101 HCC patients were diagnosed and stratified according to 7 different staging systems; along with analysis of independent predictors of survival and their correlation with it (Kaplan-Meier analysis).
RESULTS: CLIP, Tokyo score and BCLC staging system showed a significant difference in the probability of survival. All other staging systems failed to show a significant difference in survival. Age, portal vein thrombosis, serum bilirubin, MELD score showed a significant difference with survival in univariate analysis. However, serum bilirubin was the independent predictor of survival with a hazard ratio of 1.609 (95% CI 1.015-2.553, p = 0.043).
CONCLUSION: The CLIP, Tokyo score and BCLC are the most useful staging systems in an Indian cohort.
METHODS: In this prospective study, 101 HCC patients were diagnosed and stratified according to 7 different staging systems; along with analysis of independent predictors of survival and their correlation with it (Kaplan-Meier analysis).
RESULTS: CLIP, Tokyo score and BCLC staging system showed a significant difference in the probability of survival. All other staging systems failed to show a significant difference in survival. Age, portal vein thrombosis, serum bilirubin, MELD score showed a significant difference with survival in univariate analysis. However, serum bilirubin was the independent predictor of survival with a hazard ratio of 1.609 (95% CI 1.015-2.553, p = 0.043).
CONCLUSION: The CLIP, Tokyo score and BCLC are the most useful staging systems in an Indian cohort.