American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2004
Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Koizumi Hiroki, Hashimoto Kenji, Itoh Kanako, Nakazato Michiko, Shimizu Eiji, Ohgake Shintaro, Koike Kaori, Okamura Naoe, Matsushita Sachio, Suzuki Kenji, Murayama Masanobu, Higuchi Susumu, Iyo Masaomi
Аннотация
Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain-derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the BDNF gene in the susceptibility to eating disorders, we analyzed the BDNF 196G/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n = 198) and normal controls (n = 222) was statistically significant (P = 0.029). Interestingly, a significant (P = 0.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n = 101) with binge-purging type was detected. This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.