Clinical psychology review · 2017
Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Santesteban-Echarri Olga, Paino Mercedes, Rice Simon, González-Blanch César, McGorry Patrick, Gleeson John, Alvarez-Jimenez Mario
Аннотация
BACKGROUND: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes.
AIMS: To systematically compile and analyse predictors of functional recovery in FEP.
METHOD: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP.
RESULTS: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N=6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery.
CONCLUSIONS: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP.
AIMS: To systematically compile and analyse predictors of functional recovery in FEP.
METHOD: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP.
RESULTS: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N=6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery.
CONCLUSIONS: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP.