Radiation oncology (London, England) · 2025
SSTR PET/CT for skull base low-grade meningioma: a critical tool for accurate gross tumor volume delineation in radiotherapy?
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Fuchs Frederik, Marschner Sebastian N, Hofmaier Jan, Rottler Maya, Hadi Indra, Maier Sebastian H, Greve Tobias, Holzgreve Adrien, Albert Nathalie L, Bodensohn Raphael, Belka Claus, Niyazi Maximilian, Walter Franziska
Аннотация
BACKGROUND: Precise delineation of gross tumor volume (GTV) is fundamental for effective radiation therapy in low-grade skull base meningiomas. Magnetic resonance imaging (MRI) serves as the primary imaging tool but may not fully represent tumor extent. This study investigates the additional value of incorporating Somatostatin receptor (SSTR)-directed PET/CT in radiation therapy planning.
METHODS: A retrospective analysis was conducted with four experienced radiation oncologists contouring GTVs for skull base meningiomas using MRI alone (GTV_MRI), PET/CT alone (GTV_PET/CT), and both modalities combined (GTV_ALL). Consensus ground truth volumes were generated for each modality through a STAPLE algorithm. Agreement between modalities, excluding observer variability, was assessed using statistical metrics including Dice Similarity Coefficient (DSC), Jaccard Index (JCI), Hausdorff distance (HD95), Geographical Miss Index (GMI), sensitivity, and kappa statistics.
RESULTS: The study included 25 patients (15 females, 10 males; median age 56 years (range: 23-74 years), with 96% achieving local control post-radiotherapy over a median follow-up of 64 months (range: 28-135 months). Substantial interobserver agreement was observed, with median kappa values of 0.74 for GTV_MRI, 0.68 for GTV_PET/CT, and 0.77 for GTV_ALL. Median consensus volumes were 6.65 cc (MRISTAPLE), 7.21 cc (PETSTAPLE), and 6.73 cc (ALLSTAPLE). The median GMI for MRISTAPLE compared to ALLSTAPLE was 0.18 (IQR: 0.11-0.39), and 0.21 (IQR: 0.15-0.28) for PETSTAPLE compared to ALLSTAPLE. The DSC indicated the lowest concordance between MRISTAPLE and PETSTAPLE with a median of 0.75 (IQR: 0.59-0.82), followed by PETSTAPLE versus ALLSTAPLE with a median DSC of 0.84 (IQR: 0.79-0.89), and MRISTAPLE versus ALLSTAPLE with a median DSC of 0.89 (IQR: 0.76-0.92). The integration of PET/CT with MRI significantly enhanced concordance metrics.
CONCLUSION: Combining MRI and PET/CT improves GTV delineation in low-grade skull base meningiomas, as PET/CT can reveal regions missed by MRI, which may slightly underestimate tumor size. This multimodal imaging approach enhances consensus and supports its role in radiotherapy planning. Standardized protocols and technical integration remain key future goals.
METHODS: A retrospective analysis was conducted with four experienced radiation oncologists contouring GTVs for skull base meningiomas using MRI alone (GTV_MRI), PET/CT alone (GTV_PET/CT), and both modalities combined (GTV_ALL). Consensus ground truth volumes were generated for each modality through a STAPLE algorithm. Agreement between modalities, excluding observer variability, was assessed using statistical metrics including Dice Similarity Coefficient (DSC), Jaccard Index (JCI), Hausdorff distance (HD95), Geographical Miss Index (GMI), sensitivity, and kappa statistics.
RESULTS: The study included 25 patients (15 females, 10 males; median age 56 years (range: 23-74 years), with 96% achieving local control post-radiotherapy over a median follow-up of 64 months (range: 28-135 months). Substantial interobserver agreement was observed, with median kappa values of 0.74 for GTV_MRI, 0.68 for GTV_PET/CT, and 0.77 for GTV_ALL. Median consensus volumes were 6.65 cc (MRISTAPLE), 7.21 cc (PETSTAPLE), and 6.73 cc (ALLSTAPLE). The median GMI for MRISTAPLE compared to ALLSTAPLE was 0.18 (IQR: 0.11-0.39), and 0.21 (IQR: 0.15-0.28) for PETSTAPLE compared to ALLSTAPLE. The DSC indicated the lowest concordance between MRISTAPLE and PETSTAPLE with a median of 0.75 (IQR: 0.59-0.82), followed by PETSTAPLE versus ALLSTAPLE with a median DSC of 0.84 (IQR: 0.79-0.89), and MRISTAPLE versus ALLSTAPLE with a median DSC of 0.89 (IQR: 0.76-0.92). The integration of PET/CT with MRI significantly enhanced concordance metrics.
CONCLUSION: Combining MRI and PET/CT improves GTV delineation in low-grade skull base meningiomas, as PET/CT can reveal regions missed by MRI, which may slightly underestimate tumor size. This multimodal imaging approach enhances consensus and supports its role in radiotherapy planning. Standardized protocols and technical integration remain key future goals.