IJID regions · 2025
Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study.
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Abu-Shomar Reem, Zeitoun Mark, Abbara Aula, Elmanama Abdelraouf
Аннотация
OBJECTIVES: To assess the antibiotic resistance profile, multiple antibiotic resistance index (MARI), and genetic determinants of Pseudomonas spp. isolated from water sources in primary health care centers in Gaza. This investigation aimed to understand potential risks for nosocomial transmission, particularly in the context of deteriorating healthcare and water infrastructure in conflict zone.
METHODS: A total of 64 water samples were collected from five primary health care centers across Gaza (April-August 2022). Isolates were identified using standard microbiological techniques. Antibiotic susceptibility was tested via the Kirby-Bauer disk diffusion method; MARI was calculated, and polymerase chain reaction was used to detect New Delhi metallo-β-lactamase (NDM) genes.
RESULTS: Pseudomonas spp. were isolated from 59.4% of samples (desalinated: 48.3%; municipal: 68.6%). High resistance was observed to imipenem (84%) and piperacillin (84%), followed by aztreonam (31.6%) and gentamicin (28.9%). The average MARI was 0.4. NDM genes were detected in a subset of isolates.
CONCLUSIONS: The presence of multidrug-resistant, NDM-producing Pseudomonas in reverse osmosis and municipal water highlights the urgent need for water safety, screening, and infection control in conflict-affected health care settings.
METHODS: A total of 64 water samples were collected from five primary health care centers across Gaza (April-August 2022). Isolates were identified using standard microbiological techniques. Antibiotic susceptibility was tested via the Kirby-Bauer disk diffusion method; MARI was calculated, and polymerase chain reaction was used to detect New Delhi metallo-β-lactamase (NDM) genes.
RESULTS: Pseudomonas spp. were isolated from 59.4% of samples (desalinated: 48.3%; municipal: 68.6%). High resistance was observed to imipenem (84%) and piperacillin (84%), followed by aztreonam (31.6%) and gentamicin (28.9%). The average MARI was 0.4. NDM genes were detected in a subset of isolates.
CONCLUSIONS: The presence of multidrug-resistant, NDM-producing Pseudomonas in reverse osmosis and municipal water highlights the urgent need for water safety, screening, and infection control in conflict-affected health care settings.