HNO · 2015
[Role of vitamin D in allergic diseases: Current research status].
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Sperl A, Klimek L
Аннотация
BACKGROUND: Recent research has focused on the relationship between vitamin D and allergy development. Results show that on the one hand a vitamin D deficiency can be responsible for the emergence of allergies, however, on the other hand a vitamin-D (over-) substitution was also seen in context with an increased allergy development.
OBJECTIVE: This article provides an overview on the current state of research and points at the problematic aspects that accompany the assessment of these studies.
RESULTS: The paradoxic effect of vitamin D is currently being explained by epigenetic programming in pregnancy, by too low vitamin-D levels or excessive supplementation in newborns. Very recently, a gender-specific impact of vitamin D is also being discussed.
CONCLUSION: For a final assessment of vitamin-D effects on the emergence of allergies, further research is necessary. Due to a high level of heterogeneity among current observational studies regarding central aspects of the discussion, randomised clinical trials are recommended.
OBJECTIVE: This article provides an overview on the current state of research and points at the problematic aspects that accompany the assessment of these studies.
RESULTS: The paradoxic effect of vitamin D is currently being explained by epigenetic programming in pregnancy, by too low vitamin-D levels or excessive supplementation in newborns. Very recently, a gender-specific impact of vitamin D is also being discussed.
CONCLUSION: For a final assessment of vitamin-D effects on the emergence of allergies, further research is necessary. Due to a high level of heterogeneity among current observational studies regarding central aspects of the discussion, randomised clinical trials are recommended.