Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2005
Genetic analysis of dog rabies viruses circulating in Bangkok.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Khawplod Pakamatz, Shoji Yoko, Ubol Sukathida, Mitmoonpitak Channarong, Wilde Henry, Nishizono Akira, Kurane Ichiro, Morimoto Kinjiro
Аннотация
The genetic diversity of the rabies virus glycoprotein (G) gene isolated from individual rabid dogs (inter-hosts) and within a single infected dog (intra-host) has been analyzed in an effort to better understand selective pressures and population shifts among rabies viruses circulating in Bangkok. Comparison of individual master sequences among inter-hosts revealed that the dog virus isolates circulating in Bangkok were phylogenetically closely related. The ectodomain of the glycoprotein was highly conserved among the virus isolates. Furthermore, the genetic diversity of the G gene within an intra-host was assessed by comparing the cloned sequences in the virus population. The comparisons revealed that rabies virus circulating in an intra-host consisted of closely related heterogenous populations with minor substitutions at nucleotide (0.19%) and amino acid levels.
Предметные рубрики MeSH
Amino Acid SequenceAmino Acid SubstitutionAnimalsBase SequenceCloning, MolecularDog DiseasesDogsGenetic VariationGlycoproteinsMolecular Sequence DataNucleic Acid Amplification TechniquesPhylogenyPolymerase Chain ReactionProtein Structure, TertiaryRNA, ViralRabiesRabies virusReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNAThailand