European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2024
Perioperative management and survival outcomes following cytoreductive surgery in patients with peritoneal metastases from rectal cancer: A scoping review.
СтатьяScoping ReviewНазвание и аннотация: Перевод пока не подготовлен
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Brière Raphaëlle, Simard Anne-Julie, Rouleau-Fournier François, Letarte François, Drolet Sébastien, Brind'Amour Alexandre
Аннотация
BACKGROUND: Patients with rectal cancer and peritoneal metastases (PM) may have a worse prognosis and benefit from a different management than patients with colon cancer.
METHODS: A systematic literature search of MEDLINE (PubMed) and EMBASE databases was performed to identify all reported patients with rectal cancer and PM treated with cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal chemotherapy (HIPEC), to investigate the proper selection criteria for this population, the optimal perioperative management, and highlight its specific oncological outcomes.
RESULTS: Twenty studies reporting on 285 patients were identified. Median age varied from 28 to 63 years, and 57.5 % of patients had synchronous disease. The use of neoadjuvant treatment was frequent, but regimens were heterogenous, consisting of radiotherapy alone, chemoradiotherapy or systemic chemotherapy. Thirty-two percent did not receive any neoadjuvant treatment. Most patients (85.6 %) received HIPEC after CRS, with mitomycin C being the most used drug. Complete cytoreduction was performed in 90.1 % of patients. Data on stoma creation and management were poorly reported. Severe complications occurred in 32.2 % of patients. Median disease-free survival ranged from 6 to 22 months, and median overall survival varied from 7 to 53.2 months.
CONCLUSION: This scoping review highlights the paucity of data available regarding the management of patients with rectal cancer and PM. It also emphasizes different issues and dilemmas regarding this specific population, especially on the use of neoadjuvant treatment, the role of HIPEC after CRS and stoma management.
METHODS: A systematic literature search of MEDLINE (PubMed) and EMBASE databases was performed to identify all reported patients with rectal cancer and PM treated with cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal chemotherapy (HIPEC), to investigate the proper selection criteria for this population, the optimal perioperative management, and highlight its specific oncological outcomes.
RESULTS: Twenty studies reporting on 285 patients were identified. Median age varied from 28 to 63 years, and 57.5 % of patients had synchronous disease. The use of neoadjuvant treatment was frequent, but regimens were heterogenous, consisting of radiotherapy alone, chemoradiotherapy or systemic chemotherapy. Thirty-two percent did not receive any neoadjuvant treatment. Most patients (85.6 %) received HIPEC after CRS, with mitomycin C being the most used drug. Complete cytoreduction was performed in 90.1 % of patients. Data on stoma creation and management were poorly reported. Severe complications occurred in 32.2 % of patients. Median disease-free survival ranged from 6 to 22 months, and median overall survival varied from 7 to 53.2 months.
CONCLUSION: This scoping review highlights the paucity of data available regarding the management of patients with rectal cancer and PM. It also emphasizes different issues and dilemmas regarding this specific population, especially on the use of neoadjuvant treatment, the role of HIPEC after CRS and stoma management.