Frontiers in immunology · 2022
Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Nückel Julius, Planatscher Elisa, Mohr Anne Wiebe, Deichl Karolin, Mijočević Hrvoje, Feuerherd Martin, Wolff Lisa, Erber Johanna, Schneider Jochen, Quante Michael, Winter Christoph, Ruland Jürgen, Hapfelmeier Alexander, Hammerschmidt Wolfgang, Moosmann Andreas, Protzer Ulrike, Behrends Uta, Mautner Josef
Аннотация
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.