Managing Hybrid Closed-Loop Insulin Delivery in Complex Clinical Scenarios: Focus on Perioperative, Dialysis, and Glucocorticoid Use.

Hybrid closed-loop (HCL) systems have transformed outpatient diabetes management, yet their application in complex inpatient and hospital-based scenarios remains underexplored. This article examines the utilization of HCL systems in three challenging clinical contexts: the perioperative period, dialysis (hemodialysis and peritoneal dialysis), and during glucocorticoid therapy. Our article and case series examples provide an overview of the current available literature, preliminary data, and practical guidance for clinicians on HCL systems in these settings. Further research is urgently needed to establish the evidence base in this high-risk cohort.