Frontiers in endocrinology · 2025
Association between Geriatric Nutrition Risk Index and depression in older hemodialysis patients with and without type 2 diabetes mellitus: a multicenter cross-sectional study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Zhang Jinwen, Gao Jing, Gaowa Siqin, Han Peipei, Chen Xiaoyu, Cai Pingping, Guo Jiangling, Wu Qianhao, Miao Jingjie, Zhao Chengzhang, Zhang Keying, Kong Lingyao, Shui Jing, Guo Qi
Аннотация
OBJECTIVES: The purpose of this study was to observe the relationship between the Geriatric nutrition risk index (GNRI) and depression in the presence or absence of type 2 diabetes mellitus (T2DM) in older adults undergoing hemodialysis.
DESIGN: In this multicenter cross-sectional study, 684 clinically stable hemodialysis patients aged ≥60 years (431 men; mean age: 69.6 ± 6.6 years) were included from seven dialysis units in Shanghai, China. Measures: Depressive symptoms were assessed using the PHQ-9 scale, and T2DM diagnoses were determined by medical records. Multinomial logistic regression was performed to evaluate the association between Geriatric Nutritional Risk Index (GNRI) and depression.
RESULTS: Hemodialysis patients with diabetes had a high prevalence of depression (39.4%). In diabetes patients, GNRI was associated with depression after adjusting covariates [OR=0.984; 95% confidence interval (CI) = 0.969-0.999, P=0.046]. However, no significant association was found between GNRI and depression in the non-diabetes hemodialysis patients (P > 0.05).
CONCLUSIONS: This cross-sectional study examines the relationship between the GNRI and depression in hemodialysis patients with T2DM rather than the non-T2DM group. Further studies are needed to investigate more causal relationships between GNRI and depression in patients with T2DM.
DESIGN: In this multicenter cross-sectional study, 684 clinically stable hemodialysis patients aged ≥60 years (431 men; mean age: 69.6 ± 6.6 years) were included from seven dialysis units in Shanghai, China. Measures: Depressive symptoms were assessed using the PHQ-9 scale, and T2DM diagnoses were determined by medical records. Multinomial logistic regression was performed to evaluate the association between Geriatric Nutritional Risk Index (GNRI) and depression.
RESULTS: Hemodialysis patients with diabetes had a high prevalence of depression (39.4%). In diabetes patients, GNRI was associated with depression after adjusting covariates [OR=0.984; 95% confidence interval (CI) = 0.969-0.999, P=0.046]. However, no significant association was found between GNRI and depression in the non-diabetes hemodialysis patients (P > 0.05).
CONCLUSIONS: This cross-sectional study examines the relationship between the GNRI and depression in hemodialysis patients with T2DM rather than the non-T2DM group. Further studies are needed to investigate more causal relationships between GNRI and depression in patients with T2DM.