SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lizewski Rhonda A, Sealfon Rachel S G, Park Sang Woo, Smith Gregory R, Porter Chad K, Gonzalez-Reiche Ana S, Ge Yongchao, Miller Clare M, Goforth Carl W, Pincas Hanna, Termini Michael S, Ramos Irene, Nair Venugopalan D, Lizewski Stephen E, Alshammary Hala, Cer Regina Z, Chen Hua Wei, George Mary-Catherine, Arnold Catherine E, Glang Lindsay A, Long Kyle A, Malagon Francisco, Marayag Jan J, Nunez Edgar, Rice Gregory K, Santa Ana Ernesto, Schilling Megan A, Smith Darci R, Sugiharto Victor A, Sun Peifang, van de Guchte Adriana, Khan Zenab, Dutta Jayeeta, Vangeti Sindhu, Voegtly Logan J, Weir Dawn L, Metcalf C Jessica E, Troyanskaya Olga G, Bishop-Lilly Kimberly A, Grenfell Bryan T, van Bakel Harm, Letizia Andrew G, Sealfon Stuart C
Аннотация
METHODS: Between May and November 2020, we monitored 2,469 unvaccinated, mostly male, Marine recruits prospectively during basic training. If participants tested negative for SARS-CoV-2 by quantitative polymerase chain reaction (qPCR) at the end of quarantine, they were transferred to the training site in segregated companies and underwent biweekly testing for 6 weeks. We assessed the effects of coronavirus disease 2019 (COVID-19) prevention measures on other respiratory infections with passive surveillance data, performed phylogenetic analysis, and modeled transmission dynamics and testing regimens.
RESULTS: Preventive measures were associated with drastically lower rates of other respiratory illnesses. However, among the trainees, 1,107 (44.8%) tested SARS-CoV-2-positive, with either mild or no symptoms. Phylogenetic analysis of viral genomes from 580 participants revealed that all cases but one were linked to five independent introductions, each characterized by accumulation of mutations across and within companies, and similar viral isolates in individuals from the same company. Variation in company transmission rates (mean reproduction number R 0 ; 5.5 [95% confidence interval [CI], 5.0, 6.1]) could be accounted for by multiple initial cases within a company and superspreader events. Simulations indicate that frequent rapid-report testing with case isolation may minimize outbreaks.
CONCLUSIONS: Transmission of wild-type SARS-CoV-2 among Marine recruits was approximately twice that seen in the community. Insights from SARS-CoV-2 outbreak dynamics and mutations spread in a remote, congregate setting may inform effective mitigation strategies.