Journal of stomatology, oral and maxillofacial surgery · 2024
The discovery of migratory lesion in mandibular sclerosing osteomyelitis during biological inhibitors therapy: Two cases report and literature review.
СтатьяКлинический случайОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Han Weihua, Wang Mu, Kong Ge, Li Chen, Zhang Wen, Zhou Lian
Аннотация
BACKGROUND: Diffuse sclerosing osteomyelitis (DSO) in mandible is a disease with unusual and undefined clinicoradiographic manifestations. Several medicines have been administrated for therapy, but the efficacy in bone remolding remains to be systematically evaluated.
OBSERVATION: A 37-year-old male and a 28-year-old female were diagnosed DSO after revealing diffuse sclerosis and osteolytic changes in the mandible, and treated by Janus-activated kinase signal and IL-6 inhibitor, respectively. Their symptoms were well controlled and the inflammatory indicators were decreased. During the mandible remolding, the osteolytic destruction in one patient migrated from the left mandible to the right, while DSO lesion migrated from the left mandibular body to the ramus and condyle in the other.
CONCLUSION: DSO presented as migratory lesions in mandible after biological inhibitors therapy, while the periosteal reaction wasn't conformed to the osteolytic focus. These findings suggest that periostitis may be the direct cause of DSO rather than the infectious triggers.
OBSERVATION: A 37-year-old male and a 28-year-old female were diagnosed DSO after revealing diffuse sclerosis and osteolytic changes in the mandible, and treated by Janus-activated kinase signal and IL-6 inhibitor, respectively. Their symptoms were well controlled and the inflammatory indicators were decreased. During the mandible remolding, the osteolytic destruction in one patient migrated from the left mandible to the right, while DSO lesion migrated from the left mandibular body to the ramus and condyle in the other.
CONCLUSION: DSO presented as migratory lesions in mandible after biological inhibitors therapy, while the periosteal reaction wasn't conformed to the osteolytic focus. These findings suggest that periostitis may be the direct cause of DSO rather than the infectious triggers.