Contact dermatitis · 2013
Patch testing and sensitization to multiple drugs.
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Liippo Jussi, Pummi Kati, Hohenthal Ulla, Lammintausta Kaija
Аннотация
BACKGROUND: Adverse drug reactions pose an increasing diagnostic challenge in hospitals and in outpatient clinics. When consecutive or repeated allergic drug eruptions are suspected, patch testing is a useful diagnostic tool for determining the causative drugs.
OBJECTIVES: The aim of the study was to identify patient cases with multiple delayed-type drug sensitizations by using patch testing.
METHODS: Eight hundred and eleven patients with suspected drug allergy were patch tested during a 9-year period.
RESULTS: Multiple delayed drug sensitizations were found in 12% of those patients with positive results in drug patch testing.
CONCLUSIONS: Drug patch testing is useful in cutaneous adverse drug reactions where multiple drugs are suspected. Multiple drug sensitizations can be found in a proportion of patients who have delayed drug allergies. In addition to drug reactions with eosinophilia and systemic symptoms, these patients may have repeated exanthemas or contact dermatitis.
OBJECTIVES: The aim of the study was to identify patient cases with multiple delayed-type drug sensitizations by using patch testing.
METHODS: Eight hundred and eleven patients with suspected drug allergy were patch tested during a 9-year period.
RESULTS: Multiple delayed drug sensitizations were found in 12% of those patients with positive results in drug patch testing.
CONCLUSIONS: Drug patch testing is useful in cutaneous adverse drug reactions where multiple drugs are suspected. Multiple drug sensitizations can be found in a proportion of patients who have delayed drug allergies. In addition to drug reactions with eosinophilia and systemic symptoms, these patients may have repeated exanthemas or contact dermatitis.