Healthy lifestyle and the risk of pancreatic cancer in the EPIC study.
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Naudin Sabine, Viallon Vivian, Hashim Dana, Freisling Heinz, Jenab Mazda, Weiderpass Elisabete, Perrier Flavie, McKenzie Fiona, Bueno-de-Mesquita H Bas, Olsen Anja, Tjønneland Anne, Dahm Christina C, Overvad Kim, Mancini Francesca R, Rebours Vinciane, Boutron-Ruault Marie-Christine, Katzke Verena, Kaaks Rudolf, Bergmann Manuela, Boeing Heiner, Peppa Eleni, Karakatsani Anna, Trichopoulou Antonia, Pala Valeria, Masala Giovana, Panico Salvatore, Tumino Rosario, Sacerdote Carlotta, May Anne M, van Gils Carla H, Rylander Charlotta, Borch Kristin Benjaminsen, Chirlaque López María Dolores, Sánchez Maria-Jose, Ardanaz Eva, Quirós José Ramón, Amiano Exezarreta Pilar, Sund Malin, Drake Isabel, Regnér Sara, Travis Ruth C, Wareham Nick, Aune Dagfinn, Riboli Elio, Gunter Marc J, Duell Eric J, Brennan Paul, Ferrari Pietro
Аннотация
Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants' shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e-09) and 0.77 (0.72, 0.82; ptrend = 1.7e-15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e-04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.