Journal of human genetics · 2009
Genome-wide association study of panic disorder in the Japanese population.
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Otowa Takeshi, Yoshida Eiji, Sugaya Nagisa, Yasuda Shin, Nishimura Yukika, Inoue Ken, Tochigi Mamoru, Umekage Tadashi, Miyagawa Taku, Nishida Nao, Tokunaga Katsushi, Tanii Hisashi, Sasaki Tsukasa, Kaiya Hisanobu, Okazaki Yuji
Аннотация
Panic disorder (PD) is an anxiety disorder characterized by panic attacks and anticipatory anxiety. Although a number of association studies have been conducted, no gene has been identified as a susceptibility locus. In this study, we conducted a genome-wide association study of PD in 200 Japanese patients and the same number of controls, using the GeneChip Human Mapping 500 K Array Set. Genotypes were determined using the Bayesian Robust Linear Model with Mahalanobis (BRLMM) genotype calling algorithm. The genotype data were data-cleaned using criteria for SNP call rate (>or=95%), Hardy-Weinberg equilibrium (P>or=0.1%) and minor allele frequency (>or=5%). The significance level of the allele P-value was set at 1.0 x 10(-6), to make false discovery rate (FDR) <0.05. As a result, seven SNPs were significantly associated with PD, which were located in or adjacent to genes including PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J). Studies with other samples are required to confirm the results.