[BIOMARKER CONTENT AND ROLE IN HOSPITAL PERIOD OF ACUTE CORONARY SYNDROME].

The study involved 172 patients with coronary heart diseases (CHD) of whom 146 presented with acute coronary syndrome (ACS) including 88 with myocardial infarction (MI), 58 with unstable angina (UA) and 26 with FC II-III stable angina (SA). Interleukin (IL-6, 10), natriuretic peptide (NT-proBNP) levels in blood and 6-hydroxymelatonin level in urine were determined on days 1-3 after hospitalization. These daytime values in ACS were higher than in SA whereas the melatonin level at night was higher in SA than in ACS. Patients with ACS in the absence of ST elevation had higher IL and melatonin (night) levels but lower NT-proBNP and melatonin daytime levels than patients with ACS and elevated ST segment. IL-6 , 10 and melatonin (night and daytime) levels in MI were lower and NT-proBNP level higher than in UA. IL-6, 10 and melatonin daytime levels increased in uncomplicated ACS while melatonin (night) and NT-proBNP levels were higher in complicated ACS.