Archives of neurology · 2009
Diffusion abnormalities in the primary sensorimotor pathways in writer's cramp.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Delmaire Christine, Vidailhet Marie, Wassermann Demian, Descoteaux Maxime, Valabregue Romain, Bourdain Frédéric, Lenglet Christophe, Sangla Sophie, Terrier Axel, Deriche Rachid, Lehéricy Stéphane
Аннотация
OBJECTIVE: To determine whether there are diffusion abnormalities along the fibers connecting sensorimotor regions, including the primary sensorimotor areas and the striatum, in patients with writer's cramp using voxel-based diffusion analysis and fiber tracking. Recent studies have shown structural changes in these regions in writer's cramp.
DESIGN: Patient and control group comparison.
SETTING: Referral center for movement disorders.
PARTICIPANTS: Twenty-six right-handed patients with writer's cramp and 26 right-handed healthy control subjects matched for sex and age.
INTERVENTIONS: Clinical motor evaluations.
MAIN OUTCOME MEASURES: Fractional anisotropy changes and results of fiber tracking in writer's cramp.
RESULTS: Diffusion-tensor imaging revealed increased fractional anisotropy bilaterally in the white matter of the posterior limb of the internal capsule and adjacent structures in the patients with writer's cramp. Fiber tracking demonstrated that fractional anisotropy changes involve fiber tracts connecting the primary sensorimotor areas with subcortical structures.
CONCLUSIONS: Diffusion abnormalities are present in fiber tracts connecting the primary sensorimotor areas with subcortical structures in writer's cramp. These abnormalities strengthen the role of the corticosubcortical pathways in the pathophysiologic mechanisms of writer's cramp.
DESIGN: Patient and control group comparison.
SETTING: Referral center for movement disorders.
PARTICIPANTS: Twenty-six right-handed patients with writer's cramp and 26 right-handed healthy control subjects matched for sex and age.
INTERVENTIONS: Clinical motor evaluations.
MAIN OUTCOME MEASURES: Fractional anisotropy changes and results of fiber tracking in writer's cramp.
RESULTS: Diffusion-tensor imaging revealed increased fractional anisotropy bilaterally in the white matter of the posterior limb of the internal capsule and adjacent structures in the patients with writer's cramp. Fiber tracking demonstrated that fractional anisotropy changes involve fiber tracts connecting the primary sensorimotor areas with subcortical structures.
CONCLUSIONS: Diffusion abnormalities are present in fiber tracts connecting the primary sensorimotor areas with subcortical structures in writer's cramp. These abnormalities strengthen the role of the corticosubcortical pathways in the pathophysiologic mechanisms of writer's cramp.